Introduction to bioinformatics: basic principles of computing and bioinformatics; collecting and storing sequence data in laboratory; alignment of pairs of sequences and multiple sequence alignments; phylogenetic analysis of homologous sequences; database searches for similar sequences; structural bioinfromatics; predicting secondary structure from protein sequences; gene prediction; proteomics data analysis; bioinformatics in pharmaceutical industry. - types and retrieval of nucleic acid (or genomic) or protein sequence information; sequence alignment - pairwise, multiple; phylogenetics; in silico identification of protein motifs and domains; structural bioinformatics of proteins and RNAs including protein modeling and prediction of their interactions with other proteins and small molecules; identification of genes and promoter regions within genomes; networks; strategies for whole genome sequencing and assembly.
Individuals with skills in bioinformatics are, today, keenly sought by biotechnology industry and academia to derive forward research and development in many areas of biology.
Course Learning Outcomes
Aim of this course is to provide up-to-date biological information and use of computer methods/databases for the generation, storage, analysis and interpretation of this information, to the students.
Introduction to bioinformatics
BLAST, FASTA, local and global sequence alignment
databases and its types with examples
NCBI database (Sequence retrieval and alignment)
Human genome database (Sequence retrieval and alignment)
Primer designing with primer 3 software
Book Title : Introduction to bioinformatics
Author : TK Attwood, D J Parry-Smith, Samiron Phukan
Edition : First
Publisher : Dorling Kindersley India
Book Title : Bioinformatics A modern Approaches
Author : Vittal R. Srinivas
Edition : Third
Publisher : PHI Learning Private Limited New Delhi India
Book Title : Basic Bioinformatics
Author : Manju Bansal
Edition : First
Publisher : Atlantic Publisher and Distributions (P) LTD