Course Contents

COURSE CONTENTS 1. Type of hormones; General principles in function, interaction, nature, synthesis, transport of hormones; 2. General concept of feed back, biorhythms, pathology and assessment of endocrine function. 3. Role of different receptors in the Molecular mechanism of different hormones. 4. Hypothalamus and pituitary: Hypothalamic hormones: Origin, chemistry and actions; Anterior pituitary & hormones: Hypothalamic pituitary regulation, General chemistry, Physiological action and metabolism of prolactin-growth hormone family, glycoprotein hormone family, corticotrophins and other proopiomelanocortin peptides; posterior pituitary: Release, regulation and actions of vasopressin and oxytocin. 5. Thyroid gland: Formation and secretion of thyroid hormones; Molecular Mechanism of Thyroid hormones action in peripheral tissues, Regulation and factors affecting thyroid function. 6. Calciotrophic and Mineral Metabolism Hormones: Chemistry, Molecular Mechanism of actions and metabolism of parathyroid hormone, calcitonin and calciferols; Homeostasis of calcium, phosphate and magnesium. 7. Pancreatic Hormones and Regulatory Peptides of the Gut: Chemistry, physiological roles and molecular mechanism of action of insulin and glucagon; Physiological roles of gut peptides at cellular level. 8. Adrenal Medulla and Catecholamines: Chromaffin cell and organization; Biosynthesis, storage, release and metabolism; Adrenergic receptors.Adrenal Cortex: Steroid biochemistry; Molecular mechanism of action of corticoid hormones; and adrenal sex steroids. 9. Testes: Androgenic tissue: Structure and chemistry; Transport, metabolism and molecularmechanism of action. 10. Ovaries: Ovarian hormones: Steroid biochemistry and biosynthesis; Transport, metabolism and mechanism of action at cellular level. Books Recommended 1. Basic and clinical endocrinology.Greenspan, F.S. and Strewler, G.J., 2002. 5th Edition. Prentice Hall International Inc., London. 2. Williams Textbook of Endocrinology, Wilson, J.D., Foster, D.W., Kronenberg, H.M. and Larsen, P.R., 1998. 9th Edition. W.D. Saunders Company, Philadelphia. 3. Endocrinology.DeGroot, L.J., Jameson, J.L. et al., 2001. Vol.I, II, III, 4th ed. W.B. Saunders, Philadelphia. 4. Textbook of Endocrine Physiology.Giffin, J.E. and Ojeda, S.R., 2000. 4th Edition. Oxford University Press, Oxford. 5. Basic Endocrinology: An interactive approach. Neal, J.M., 2000. Blackwell Science Inc., London.