Course Contents

1. SEPARATION AND ISOLATION OF PLANT CONSTITUENTS: Introduction and use of spectroscopic and chromatographic techniques for the identification of natural products. Description and interpretation of ultraviolet, infrared, mass, nuclear magnetic resonance (1H-NMR and 13C-NMR) and other advance techniques to elucidate the structure of natural products. 2. CARBOHYDRATES AND RELATED COMPOUNDS: Introduction and classification of carbohydrates, sugars as adjuvant in drugs, role of impurities in sugar substances. (a) Sucrose and Sucrose containing drugs: Sucrose, Dextrose, Liquid glucose, Fructose, Lactose, Xylose, Caramel, Starch, Inulin, Dextrine etc. 82 (b) (C) Cellulose and Cellulose Derivatives: Powdered cellulose, microcrystalline cellulose, Methyl cellulose, Sodium Carboxy-methyl cellulose. Gums and Mucilage: Tragacanth, Acacia, Sodium Alginate, Agar, Pectin. 3. ALKALOIDS: Introduction, Properties, Classification, Function of alkaloids in plants, Methods of extraction and identification tests. (a) (b) (c) (d) (e) (f) (g) (h) (i) Pyridine Piperidine Alkaloids: Areca nut, Lobelia. Tropane Alkaloids: Belladonna, Hyoscyamus, Stramonium. Quinoline Alkaloids: Cinchona. Isoquinoline Alkaloids: Ipecacuanha, Opium. Indole alkaloids: Rauwolfia, Catharanthus, Nux vomica, Physostigma, Ergot. Imidazole alkaloids: Pilocarpus. Steroidal alkaloids: Veratrum. Alkaloidal amines: Ephedra, Colchicum. Purine Bases: Tea, Coffee. 4. GLYCOSIDES: Introduction, classification, chemistry, extraction, isolation and medicinal uses of: (a) (b) (c) (d) (e) (f) (g) (h) Cardioactive glycosides: Digitalis, Strophanthus and white squill. Anthraguinone glycosides: Cascara, Aloe, Rhubarb, Cochineal and Senna. Saponin glycosides: Glycyrrhiza, Sarsaparilla. Cyanophore glycosides: Wild cherry. Isothiocyanate glycosides: Black mustard. Lactone glycosides: Cantharide. Aldehyde glycosides: Vanilla. Miscellaneous glycosides: Gentian, Quassia, Dioscorea. 5. PLANT STEROIDS: Introduction, extraction, isolation, nomenclature, sources and uses of bile acids, plant sterols, steroidal sapogenins, steroid hormones, withanolides and ecdysons. 6. LIPIDS: Introduction, classification, source, active constituents and pharmacological uses of: (a) Fixed Oils: Castor oil, Cotton seed oil, olive oil, Peanut oil, Sun flower oil, Corn oil, Coconut oil, Almond oil, Linseed oil, Mustard oil, Sesame oil and Soybean oil. (b) Fats and Related Compounds: Theobroma oil and Lanolin. (C) Waxes: Bees wax, carnauba wax, spermaceti and Jojoba oil. 7. VOLATILE OILS (ESSENTIAL OILS): Introduction, significance, sources, active constituents, methods of obtaining volatile oils, chemistry and classification of: (a) (b) (C) (d) Hydrocarbon volatile oils: Cubeb and Turpentine oil. Alcoholic volatile oils: Peppermint, Coriander and Cardamom. Aldehydic volatile oils: Bitter orange peel, Sweet orange peel, Lemon Cinnamon and Bitter almond oil Ketonic volatile oils: Camphor, Spearmint, Caraway, Buchu 83 (e) (f) (g) (h) (i) Phenolic volatile oils: Clove, Thyme. Phenolic ether volatile oils: Fennel, Anise, Myristica. Oxide volatile oils: Eucalyptus, Chenopodium. Ester volatile oils: Rosemary. Miscellaneous volatile oils: Allium, Anethum. 8. RESINS AND OLEORESINS: Introduction, classification, active constituents and pharmacological uses of jalap, turpentine, asafoetida, benzoin, rosin, cannabis, podophyllum, ipomea, myrrh, and balsam. 9. TANNINS: Introduction, classification, biosynthesis, extraction, identification, occurrence in plants, role in plant life and chemical study of tannins in Kino, Myrobalan, Catechu, Nutgall, Castanea and krameria. 10. NATURAL TOXICANTS: 3) b) C) d) C) General Introduction to Plant Toxicology: Definition, classification and chemical nature of plant toxins. Plant toxicities in humans and animals Higher Plant Toxins: Essential oils: Terpene (cineol, pine oil), Phenyl propane (apiol, safrole, myristicin), Monoterpene (thujone, menthafuran) Plant acids (oxalic acid, amino acid, resin acid), Glycosides (cardiotonic, cyanogenic), Alkaloids (imidazole, pyrrolizidine, tropane). Lower Plant Toxins: Bacterial toxins (Staphylococcus aureus, Clostridium botulinum), Algal toxins (Microcystis aeruginosa, Cyanobecteria, Gonyaulax cantenella). Mycotoxins: Fungal toxins (Aspergillus spp., Claviceps purpurea), Mushrooms (Amanita spp.). Study of Toxins, their Prevention and Control Methods: Description, pharmacognostic features, pharmacological actions, chemical constituents, treatment, side-effects, contra-indications, warnings, prevention and control methods of Abrus precatorius, Papaver somniferum, Eucalyptus spp., Nicotiana tabaccum, Cannabis sativa, Digitalis purpurea, Datura stramonium etc. poisoning. 11. AN INTRODUCTION TO NUTRACEUTICALS AND COSMECEUTICALS: 12. TUMOUR INHIBITORS FROM PLANTS: Introduction of anticancer agents of natural origin, as Catharanthus roseus, Colchicum autumnale, Podophyllum peltatum, rifamycin antibiotics, macrolide antibiotics, anti-AIDS agents and immunostimulants. 13. INTRODUCTION TO CLINICAL PHARMACOGNOSY: General introduction and historical background of clinical Pharmacognosy. Study of treatment by herbal medicines. 84 14. CLINICAL USE OF HERBS & HERBAL MEDICINE: Diabetes: Gymnema sylvestre, Melia azadirchta, Momordica charantia, Syzygiumjambulana. Cardiac diseases: Digitalis spp., Convallaria majalis, Urgenia indica, Allium sativum, Punica granatum. Hepatitis: Berberis vulgaris, Picrorhiza kurroa, Lawsonia in. Respiratory diseases: Ficus religosa, Adhatoda vasica. Skin diseases: Aloe vera, Angelica archangelica, Mentha piperita, Citrus spp., Commiphora mukul. CNS disorders: Strychnos nux-vomica, Datura stramonium, Cannabis sativa, Papaver somniferum, Atropa belladonna. Musculo-skeletal disorders: Nigella sativa, Phycotis ajowan, Trigonella foenum-graecum, Zingiber ofi‘icinale. Renal disorders: Cucumis melo, Berberis vulgaris, Zea mays, Tribulus terrestris. Reproductive disorders: Saraca indica, Ruta graveolens, Nigella sativa, Glycyrrhiza glabra, Claviceps purpurea, Myristica fragrance. G.I.T. disorders: Foeniculum vulgare, Ferulafoetida, Cuminum cyminum, Aegle marmelos, Prunus domestica.