Course Contents

Reactive Intermediates (Carbene, Niterene), (Arynes, Free radicals), Structure, Generation, and Reactions. Benzyne and its reactions. Free radicals. Free radicals reactions like substitution, addition. Free radicals reactions like substitution, addition, rearrangements, autoxidations. Free radicals in living systems. Molecular Rearrangements involving migration to electron-deficient center. Anionotropic, Catinotropic Rearrangements. Pinacol-Pinacolone Rearrangement. Allylic Rearrangement. Neopentyl Rearrangement. Stereo-chemistry of Rearrangement Reaction. Hofmann Rearrangement. Lossen Rearrangement. Hydroperoxide Rearrangement.Benzil Benzilic acid Rearrangement. Dienone Rearrangement,Schmidt Rearrangement. Curtius Favorskii Rearrangement.Steven,rearrangement,Beckmann Rearrangement,Wolff Rearrangement.Baeyer-Villiger Rearrangement.

Course Synopsis

To learn the involvement of reactive intermediates and understand their structure and reactivity through various organic reactions Emphasis has been made on examples involving skeletal rearrangements that are practically used in day-to-day organic synthesis

Course Learning Outcomes

At the end of the course, the students should be able to understand the structure-reactivity pattern of reactive intermediates involved in organic reactions. should be able to understand how can they change the connectivity of an existing organic backbone by using reactions that result in skeletal rearrangements. students should be familiar with ring expansion and contraction by rearrangement and controlling rearrangements. understand the mechanism for the Insertion of O, N, or C next to a ketone.